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Stepfanie is best known for her lead role as the tough-minded detective Sgt. Dee Dee McCall on the NBC police drama series Hunter. Her professional acting career started in the late 1970s, while she was still in school. She guest-starred in several television shows, such as Starsky & Hutch, Dynasty, Bosom Buddies, and Knots Landing. After her departure from Hunter, she continued her work as an actress appearing in several TV shows and movies. Her most notable movie projects include Coins in the Fountain (1990), Twin Sisters (1992), Beyond Suspicion (1994), Deceived by Trust (1995), Abducted: A Fathers Love (1996), Thrill (1996), and The Dogwalker (1999). She also reprised her role as Dee Dee McCall in the two Hunter television movies. In 2015 Kramer was invited to the 55th Monte-Carlo Television festival where she was honored as an "Icon of Television". She returned to the 56th Festival in 2016 as a member of the Fiction Jury of the Festival. In 2025 she was invited to the 35th Shanghai Television Festival where she was honored for her work in Hunter, which was one of the most successful and popular television shows in China.